Table I.

Morning Subjective and Cardiovascular Responses to Prior Cumulative Dose of Oral THC in 10 Male Daily Cannabis Smokers

Variable	Day 1	Day 2	Day 4	Day 6
Subjective
Good Drug Effect*	1.5 ± 2.7	17.7 ± 18.8‡	13.0 ± 16.4	8.2 ± 11.1§
High†	3.4 ± 7.2	17.7 ± 20.5‡	11.3 ± 16.7	8.3 ± 11.2
Sedated	1.6 ± 3.1	9.9 ± 18.4	3.0 ± 5.0	4.5 ± 9.5
Stoned†	1.3 ± 2.2	7.8 ± 11.0‡	5.0 ± 7.1	4.3 ± 6.0
Stimulated	3.4 ± 5.8	4.8 ± 8.0	5.4 ± 7.4	3.1 ± 5.2
Cardiovascular
Systolic BP (mm Hg)*	129.1 ± 10.0	121.4 ± 10.5	120.4 ± 7.6	119.6 ± 6.5
Diastolic BP (mm Hg)*	74.5 ± 8.2	71.6 ± 6.2	63.1 ± 8.5	61.2 ± 8.9
Heart rate (bpm)*	59.6 ± 6.1	74.3 ± 13.4	68.8 ± 11.8	68.4 ± 12.8

Note: Responses were measured at 08:00 on Day 1 (after at least 15.5–18 h of cannabis abstinence; no prior THC administration) and just before morning THC dose on Days 2 (08:00, after 60 mg total THC), 4 (10:00, after 260 mg total THC) and 6 [10:00 (10:30 for cardiovascular variables), after 480 mg total THC]. Subjective responses were assessed with 100 mm visual-analogue scales defined as indicated. Values presented as mean ± SD.

*p < 0.05.

^†p < 0.1 for change across the six days.

^‡p < 0.05 for Day 1 versus Day 2 change.

^§p < 0.05 for Day 2 versus Day 6 change.