Table II.
Subjective and Cardiovascular Response to a Single Oral Dose of THC (20 mg) with Increasing Cumulative Exposure to Oral THC in 10 Male Daily Cannabis Smokers
| Variable | Day 2 | Day 4 | Day 6 |
|---|---|---|---|
| Subjective | |||
| Good Drug Effect | 9.3 ± 15.6 | –2.0 ± 12.1 | 1.9 ± 10.3 |
| High | 12.0 ± 14.7* | –1.8 ± 8.4 | 5.5 ± 7.6 |
| Sedated | 1.0 ± 21.4 | –4.2 ± 7.5 | 2.3 ± 6.6 |
| Stoned | 3.6 ± 6.5 | –1.8 ± 4.8 | 0.7 ± 6.3 |
| Stimulated | 1.8 ± 5.1 | 1.9 ± 7.3 | 1.1 ± 4.4 |
| Cardiovascular | |||
| Systolic BP (mm Hg) | –0.9 ± 17.6 | –8.4 ± 18.8 | –3.4 ± 22.0 |
| Diastolic BP (mm Hg) | –10.3 ± 10.8* | –15.5 ± 9.8* | –14.8 ± 5.7* |
| Heart rate (bpm) | –0.7 ± 10.9 | –5.2 ± 21.2 | –12.8 ± 8.1 |
Note: Peak change from baseline over the 3 h following the morning THC dose was measured on Days 2 (08:00 baseline, after 60 mg total THC), 4 (10:00 baseline, after 260 mg total THC) and 6 (10:00 baseline, after 480 mg total THC). Subjective responses were assessed with 100 mm visual-analogue scales defined as indicated. Values presented as mean ± SD.
*p < 0.05 for peak change from baseline.