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. 2013 Feb 26;8(2):e57435. doi: 10.1371/journal.pone.0057435

Figure 1. Gene expression profiles of Ikaros family members in mature CD8 T cells derived from Gene Expression Omnibus repository (GEO) datasets.

Figure 1

(A) Gene expression profile of human CD8 T cell subsets, including naïve (TN), effector memory (TEM) or central memory CD8 T cells (TCM) with data from GSE23321. (B) Gene expression profile of mouse CD8 T cell subsets, including naïve, effector (Eff) or memory CD8 T cells (Mem) with data from GSE10239. Differential regulation of murine Ikzf1 and Ikzf2 gene expression in P14 cells after LCMV infection with data from GSE10239. Eff expression values are the combined average of array data from sorted Klrg1int or Klrg1hi-expressing P14 cells 4.5 days after LCMV Armstrong infection as in Methods. To allow comparison of microarray hybridization intensities across different samples, microarray data were normalized using standard normalization techniques, either the RMA16 (A) or RMA (B) algorithms to normalize two different generations of Affymetrix microarrays. For both human and mouse datasets, all Ikaros family members are significantly expressed above background (DABG p-values <0.05). Gene names refer to the following gene products: Ikzf1, Ikaros; Ikzf2, Helios; Ikzf3, Aiolos; Ikzf4, Eos; Ikzf5, Pegasus.