Table 3. Significant (P<9.4×10−7; bolded) gene-level interactions affecting total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels in data from the ARIC study.
| Trait | Gene 1 | Gene 2 | P values | |||
| GG_minP | GG_GATES | GG_tTS | GG_tProd | |||
| TC | HDAC2 | HDAC1 | 1.8×10−2 | 2.3×10−3 | 1.0×10−7 | 1.9×10−4 |
| APP | APBB2 | 6.5×10−2 | 3.9×10−3 | 6.5×10−7 | 3.5×10−6 | |
| HDL-C | SMAD3 * | NEDD9 * | 2.5×10−2 | 1.2×10−2 | 8.4×10−7 | 5.0×10−7 |
| RPS6KA2 | MAPK1 | 6.2×10−3 | 8.2×10−4 | 2.6×10−7 | 2.2×10−4 | |
| KDM4A | HIST1H3F | 3.7×10−3 | 2.2×10−4 | 1.3×10−7 | 2.1×10−6 | |
*
The interaction between SMAD3 and NEDD9 on HDL-C levels was further replicated in data from the MESA study (multiple testing corrected P c = 0.01 for GG_tProd and P c = 0.05 for GG_tTS).