Figure 7. ISWI and CHD remodeler binding is positively associated with histone turnover and transcription rate.

(A) Heat maps of log₂(IP/input) signal for Chd1, Isw1, and Isw2 ±1 kb of verified ORF 5′ ranked descending by gene expression. (B) Heat maps of log₂(nucleosome turnover) and log₂(IP/input) signal for Chd1, Isw1, and Isw2 ±1 kb of verified ORF 5′ ranked descending by average nucleosome turnover across the entire 2-kb window. (C) Aggregate plots of Chd1, Isw1, and Isw2 log₂(IP/input) signal ±1 kb of verified ORF 5′ ends, separated by transcription rate in mRNA/hr [47].