TABLE 5.

Properties of S6 mutants

The values denote means ± S.E.

RyR1 mutant	Cells with caffeine response	Bmax of [3H]ryanodine bindinga	γb	PCa/PKc
	% WT	% WT	pS
Q4947N	69.7 ± 19.6 (6)d	28.3 ± 16.1 (5)d	788 ± 8 (16)	6.3 ± 0.2 (4)
Q4947T	67.7 ± 10.1 (6)d	47.9 ± 5.4 (4)d	783 ± 6 (11)	6.4 ± 0.2 (5)
Q4947S	59.8 ± 7.3 (5)d	54.8 ± 22.0 (4)d	784 ± 7 (12)	6.9 ± 0.3 (4)

^a Maximum binding capacity.

^b Conductivity.

^c Selectivity of Ca²⁺ over K⁺.

^d p < 0.05 compared with WT.