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SIK2 kinase activity, controlled by an acetylation-based regulatory switch, contributes to the progression of autophagy. Upon proteasome inhibition, SIK2 is inhibited by p300/CBP-mediated Lys-53 acetylation and sequestrated to autophagosomes. Deacetylation of SIK2 by HDAC6 in autophagosomes likely reactivates SIK2 and promotes autophagosome processing. (See text for discussion.)
