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Binding of the enzyme-malonyl thioacyl adduct. The Cys153-malonyl adduct (malonyl carbons in green) of MCR is modeled on the basis of the corresponding cysteine-aspartyl template of ASD. Although the thioacyl and the carboxylate surroundings of malonyl and aspartyl are highly conserved, the absence of the ammonium group tracks with an exchange of a glutamate and an asparagine in ASD with a tyrosine (Tyr206) and a leucine (Leu152) in MCR, respectively.
