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Dose-dependent inhibition of FNTA by manumycin A increases ApoA-I secretion. Confluent cultures of HepG2 cells were treated with manumycin A for 4 h prior to ApoA-I ELISA measurement from the culture media to determine the dose response. Data are represented as percent change (mean ± S.E. (error bars)) from cells treated with vehicle. Statistical analysis using one-way ANOVA followed by comparison with vehicle by Dunnett's method was performed (*, p < 0.01).
