FIGURE 5.

Farnesyltransferase inhibitor manumycin A regulates circulating ApoA-I in hApoA-I/hCETP mice. A, schematic representation of administration of manumycin A to hApoA-I × hCETP transgenic mice. Mice were dosed either with vehicle or manumycin A at 5 mg/kg of body weight subcutaneously 3 times per week for 2 weeks (n = 6 mice per group). At days 1 and 14, blood samples were obtained to measure serum hApoA-I levels by ELISA. Average ApoA-I levels for each group are shown (n = 6, ±S.E. (error bars)). Statistical analysis using one-way ANOVA followed by comparison with vehicle by Dunnett's method was performed. (*, p < 0.01).