FIGURE 2.
Co-localization of MMP23 with KV1.3 but not KV1.2. A and B, confocal microscopy demonstrating that MMP23-FL and MMP23-PD co-localize with YFP-Stim-1, an ER marker. YFP-Stim-1: pseudocolor green was used for the presentation. C, quantification of co-localization of MMP23-FL and MMP23-PD with KV1.3 and KV1.2. Means are determined from n samples of 10–35 for KV1.3 and 6–14 for KV1.2, respectively. Error bars indicate S.E. Statistical significance is determined by Student's t test and indicated by p values. D and E, confocal images showing that DsRed-MMP23-FL and DsRed-MMP23-PD co-localize with KV1.3-GFP but not with KV1.2-GFP, whereas the DsRed vector does not co-localize with either channel.