Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Jan 8;288(9):6451–6464. doi: 10.1074/jbc.M112.421495

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 5. — Expression of K_V1.3 and MMP23 in human colon. A, immunohistochemistry of normal human colon (at 20×) showing K_V1.3 (left) and MMP23 (right) in epithelial cells. Inset, the same isotype control was used for both K_V1.3 and MMP23; polyclonal rabbit IgG was used in place of the primary rabbit anti-K_V1.3 or rabbit anti-MMP23 antibodies. B, K_V1.3 (left, 20×) and MMP23 (right, 20×) expression in colorectal cancer. Arrows indicate adenoma (yellow) and K_V1.3- and MMP23-expressing malignant colorectal epithelium (red). C, higher magnification images of colorectal cancer showing K_V1.3 (left, 100×) and MMP23 (right, 100×). Note intracellular staining of both proteins. D, K_V1.3 (left, 20×) and MMP23 (right, 20×) in metastatic colorectal epithelium in lymph nodes. The red arrows highlight the K_V1.3- and MMP23-expressing metastatic colorectal epithelium. The surrounding lymph node is not stained. E, scoring of staining intensity on a scale of 1–3 of K_V1.3 and MMP23 in epithelium from normal colon and from three regions of colonic tissue from patients with colorectal cancer: normal-looking crypts, adenoma, and malignant epithelium.