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GPR40−/− mice exhibit an osteoporotic phenotype. A, micro-CT analysis with corresponding images of left femurs from wild-type (WT) and GRP40−/− mice (males; 16 weeks old mice; n = 11/group; BV/TV, bone volume/total volume; Tb.N, trabecular number; Tb.Sp, trabecular spaces; Tb.Th, trabecular thickness). B, bone mineral density. C, Western blot analysis of GPR40 expression in bone (tibia). Error bars represent standard deviation (±S.D.); *, p < 0.05.
