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Lethality of AP53 GAS strains. GAS cells (∼4–6 × 109 cfu for each GAS strain) of the indicated GAS cell lines were injected in C57Bl/6-hPg(Tg) mice (n = 7–10 mice for each GAS strain). Survival was monitored up to 10 days. A, bacterial strains isogenic with AP53/CovSM (WT-AP53) cells. B, NS931/CovSWT (WT-NS931) and NS931/CovSM cells. The CovS mutant generated in this strain is the same as found in WT-AP53 cells.
