TABLE 1.
CTS |
Ki |
Steroid –OH substitutions | ||
---|---|---|---|---|
pH 6.5 | pH 7.5 | pH 8.5 | ||
μm | ||||
Ouabagenin | 0.406 ± 0.077 | 2.28 ± 0.20 | 32.10 ± 0.78 | C1β, C5β, C11α, C19β |
Ouabain | 0.086 ± 0.011 | 0.091 ± 0.011 | 1.18 ± 0.27 | C1β, C5β, C11α, C19β |
Digitoxigenin | 0.132 ± 0.014 | 0.163 ± 0.018 | 0.373 ± 0.038 | |
Digitoxin | 0.183 ± 0.001 | 0.176 ± 0.012 | 0.404 ± 0.028 | |
Digoxigenin | 0.136 ± 0.006 | 0.195 ± 0.001 | 1.56 ± 0.34 | C12β |
Digoxigenin monodigitoxide | 0.107 ± 0.08 | 0.122 ± 0.012 | 0.582 ± 0.64 | C12β |
Digoxigenin didigitoxide | 0.101 ± 0.004 | 0.120 ± 0.006 | 0.614 ± 0.017 | C12β |
Digoxin | 0.102 ± 0.008 | 0.131 ± 0.020 | 1.03 ± 0.04 | C12β |
Digoxigenin tetradigitoxide | 0.078 ± 0.019 | 0.204 ± 0.014 | 1.46 ± 0.19 | C12β |
Gitoxigenin | 0.375 ± 0.055 | 0.428 ± 0.035 | 6.28 ± 0.69 | C16β |
Gitoxin | 0.144 ± 0.007 | 0.156 ± 0.012 | 0.423 ± 0.057 | C16β |
Evomonoside | 0.100 ± 0.014 | 0.106 ± 0.009 | 0.174 ± 0.002 | |
Strophanthidin | 0.139 ± 0.014 | 0.173 ± 0.038 | 0.549 ± 0.003 | C5β |
Strophanthidol | 0.170 ± 0.021 | 0.166 ± 0.025 | 1.34 ± 0.14 | C5β, C19β |
Bufalin | 0.140 ± 0.017 | 0.134 ± 0.001 | 0.271 ± 0.018 | |
Gamabufotalin | 0.154 ± 0.013 | 0.159 ± 0.022 | 0.371 ± 0.021 | C11α |