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. 2013 Feb 28;7(2):e2076. doi: 10.1371/journal.pntd.0002076

Figure 4. The analysis of HTNV nucleoprotein epitope-specific CD8+ T-cell responses with the disease severity.

Figure 4

The comparison of the epitope-specific CD8+ T-cell frequencies (A) between patients in mild/moderate group and patients in severe/critical group at the acute stage in the 18 donors with HLA-A2 or in the 8 donors with HLA-B35, (B) between the acute stage and the late stage in ten HLA-A2+ patients and in seven HLA-B35+ patients (Mann-Whitney U test). (C) The associations between the frequencies of the epitope-specific CD8+ T cells at the acute stage and the peak level of serum creatinine or nadir platelet counts during the hospitalization in 18 donors with HLA-A2 and in 8 donors with HLA-B35 (Spearman correlation test). P values of ≤0.05 were considered statistically significant. HLA, human leukocyte antigen; HFRS, hemorrhagic fever with renal syndrome.