Table 1. The nonamer CD8+ T cell epitopes on the nucleoprotein of Hantaan virus and their HLA molecule restrictions.
Patients | Severity | 15-mer peptide | Nonamer | Nonamer sequence | HLA Restriction | Frequency of pre-sensitized CD8+ T cells (SFC/106 cells) |
Donor1 | severe | aa127–aa141 | aa129–aa137 | FVVPILLKA | HLA-A2 | 145–205 |
Donor2 | critical | aa127–aa141 | aa131–aa139 | VPILLKALY | HLA-B35 | 140–190 |
Donor3 | critical | aa241–aa255 | aa247–aa255 | LPDTAAVSL | HLA-B35 | 270–305 |
Donor4 | mild | aa163–aa177 | aa167–aa175 | DVNGIRKPK | HLA-A33 | 360–380 |
aa277–aa291 | aa277–aa285 | ETKESKAIR | HLA-A33 | 165–180 |
HLA, human leukocyte antigen; SFC, spot forming cell.