Table 5. Alkaloid biosynthesis genes in sequenced isolates.^a .

		Strain
Gene	Function	A t a	C f u	C p a	C p u	E a m	E b e	E e l	E f1	E f2	E g l	E t5	E t8	N g a	N g i	N u n	P i p
EAS:
easP	Hydrolase			+											+		+
lpsC	Nonribosomal peptide synthetase		Ψ	+											+		+
easA	FMN-containing oxidoreductase		+	+	+				+	+	+	+			+		+
lpsB	Nonribosomal peptide synthetase		Ψ	+	+				+	+	+	+			+		+
cloA	Cytochrome P450 monooxygenase		+	+	+				+	+	+	+			+		+
easC	Catalase		+	+	+		+	+	+	+	+	+			+		+
easD	Short-chain alcohol dehydrogenase		+	+	+		Ψ		+	+	+	+			+		+
easE	Oxidoreductase		+	Ψ	+		+	+	+	+	+	+			+		+
easF	N-Methyltransferase		+	+	+		+	+	+	+	+	+			+		+
easG	Reductase		+	+	+		Ψ	Ψ	+	+	+	+			+		+
dmaW	Dimethylallyltryptophan synthase		+	+	+		+	+	+	+	+	+			+		+
easO	FAD-dependent monooxygenase			+											+		+
easH	Nonheme iron dioxygenase		+		+ Ψ				+	+	+	+					+
lpsA	Nonribosomal peptide synthetase				++	Ψ	Ψ		+	+	+	+					+
IDT/LTM:
idtK	Cytochrome P450 monooxygenase								+					Ψ			+
idtM	FAD-dependent monooxygenase	+		+	+				+					+			+
idtS	Unknown	+		+	+				+					+			+
idtG	Geranylgeranyl diphosphate synthase	Ψ		+					+					+			+
idtB	Unknown	+		+	+				+	+				+			+
idtC	Prenyl transferase	+		+	+				+	+				+			+
idtF	Prenyl transferase	+		+					+	+				+			+
idtP	Cytochrome P450 monooxygenase	+		+	+				+	+				+			+
idtQ	Cytochrome P450 monooxygenase	+		+	+				+	+				+			+
idtE	Multifunctional prenyltransferase								+
idtJ	Cytochrome P450 monooxygenase								+
LOL:
lolF	Monooxygenase					+	+			+	+					++
lolC	γ-Class PLP enzyme					+	+			+	+					++
lolD	α-Class PLP enzyme					+	+			+	+			Ψ		++
lolO	Nonheme iron dioxygenase					+	Ψ			+	+			Ψ		++
lolA	Amino acid binding					+	+			+	+			+		++
lolU	Unknown					+	+			+	+			Ψ		++
lolP	Cytochrome P450 monooxygenase					Ψ				+						+Ψ
lolT	α-Class PLP enzyme					+	+			+	+					++
lolE	Nonheme iron dioxygenase					+	+			+	+					++
lolN	Acetamidase									+	Ψ					+
lolM	N-Methyltransferase						Ψ			+						+
PER:
perA	Multifunctional nonribosomal peptide synthetase, methyltransferase, reductase					+	+	+	+	Δ		Δ	+

^aAbbreviations: Ata = Aciculosporium take MAFF 241224, and other strains are abbreviated as in Table 4, except that Egl = both E. glyceriae strains, E277 and E2772, which had identical sets of alkaloid genes. Symbols are: + = Apparently functional gene, Ψ  = pseudogene, Δ = deleted reductase-encoding domain of perA (perA-ΔR*). Two symbols in a cell indicate two gene copies.