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. 2013 Feb 28;8(2):e57721. doi: 10.1371/journal.pone.0057721

Figure 6. Effects of etanercept on TNF-α and IL-6 expression.

Figure 6

Protein levels of TNF-α (A) and IL-6 (B) were determined in homogenized sciatic nerves. TNF-α levels were significantly increased 2 days after crush injury, but IL-6 upregulation lasted more than 21 days. Etanercept inhibited upregulation of IL-6 levels (**p<0.01; *p<0.05; ‡p<0.01; †p<0.05, compared to the sham group).