Table 1. Interaction of Medihoney and rifampicin against S. aureus by checkerboard microdilution assay.
| MICRif a (µg/ml) | MIChoney b (%[w/v]) | FICI | synergistic | |||||
| alone | comb. | alone | comb. | |||||
| NCTC8325 | Rif | Medihoney | 0.039 | 0.0024 | 8 | 3 | 0.45 (0.07+0.38) | yes |
| Rif | manuka | 0.039 | 0.0024 | 8 | 3 | 0.45 (0.07+0.38) | yes | |
| RPAH 181 | Rif | Medihoney | 0.078 | 0.0024 | 8 | 3 | 0.41 (0.03+0.38) | yes |
| Rif | manuka | 0.078 | 0.0024 | 8 | 3 | 0.42 (0.03+0.38) | yes | |
| MW21 | Rif | Medihoney | 0.039 | 0.0024 | 8 | 3 | 0.45 (0.07+0.38) | yes |
| Rif | manuka | 0.039 | 0.0024 | 8 | 3 | 0.45 (0.07+0.38) | yes | |
| IMVS671 | Rif | Medihoney | 0.078 | 0.0024 | 8 | 3 | 0.41 (0.03+0.38) | yes |
| Rif | manuka | 0.078 | 0.0024 | 8 | 3 | 0.41 (0.03+0.38) | yes | |
| 04-227-35672 | Rif | Medihoney | 0.039 | 0.0024 | 8 | 3 | 0.45 (0.07+0.38) | yes |
| Rif | manuka | 0.039 | 0.0024 | 8 | 3 | 0.45 (0.07+0.38) | yes | |
1
MRSA strain;
2
clinical isolate;
a
MICRif is minimum inhibitory concentration of rifampicin either alone (alone) or in combination with honey (comb.);
b
MIChoney is the MIC of honey (Medihoney and manuka honey, respectively) either alone or in combination with rifampicin; Rif is rifampicin.