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. 2013 Feb 28;8(2):e57898. doi: 10.1371/journal.pone.0057898

Figure 1. MeHg-induced IL-6 mRNA upregulation and protein release from astrocytes.

Figure 1

(A) Effect of MeHg on IL-6 mRNA expression in astrocytes. MeHg (1–3 µM) transiently increased IL-6 expression and the induction peak was observed at 2 hr exposure. Low concentration of MeHg (0.1 µM) had no effect on IL-6 expression. *P<0.05 and **P<0.01 vs. control. (B) MeHg-induced IL-6 protein production to the supernatant from astrocytes. MeHg (1 or 3 µM, 12 or 24 hr) induced IL-6 production. The 12-hr exposure exhibited a lower level of IL-6 release than that with 24-hr exposure of MeHg.