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. 2013 Feb 28;8(2):e57898. doi: 10.1371/journal.pone.0057898

Figure 5. Neuro-protection by astrocyte-derived IL-6.

Figure 5

(A) The experimental schedule. MeHg (1 or 3 µM) was treated to the astrocyte culture for 24 h and the ACM was transferred into the neuronal culture. The ACM-treated neuronal cultures were further incubated for 48 h with or without IL-6 antibody. (B) ACM restored the reduction in neuronal viability evoked by MeHg (1 or 3 µM, 48 hr). The ACM-induced neuro-protection against MeHg was significantly reduced by IL-6 antibody (100 ng/ml). **P<0.01 vs. MeHg.