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. 2013 Feb 28;8(2):e56867. doi: 10.1371/journal.pone.0056867

Table 1. Relative improvement of experimental colitis with roflumilast 5 mg/kg/d and pumafentrine 5 mg/kg/d.

DSS-roflumilast (5 mg/kg/d) versusDSS-methocel (% improvement) DSS-pumafentrine (5 mg/kg/d) versusDSS-methocel (% improvement)
Clinical score (day 7) 50±3 65±5 **
Clinical score (day 11) 43±7 ** 41±7 **
Colon length (day 11) 38±1 *** 15±3 **
Histologic score (day 11) 16±4 14±3
Colonic TNFα-levels (day 11) 27±6 * 54±6 *

Data is depicted as mean ± standard error * p<0.05,

**

p<0.01,

***

p<0.001, DSS: Dextrane sodium sulfate; TNFα: tumor necrosis factor-α.

Data are depicted as % improvement of the dextrane sulfate sodium (DSS) treatment groups versus DSS methocel groups.