Table 1. Relative improvement of experimental colitis with roflumilast 5 mg/kg/d and pumafentrine 5 mg/kg/d.

	DSS-roflumilast (5 mg/kg/d) versusDSS-methocel (% improvement)	DSS-pumafentrine (5 mg/kg/d) versusDSS-methocel (% improvement)
Clinical score (day 7)	50±3	65±5 **
Clinical score (day 11)	43±7 **	41±7 **
Colon length (day 11)	38±1 ***	15±3 **
Histologic score (day 11)	16±4	14±3
Colonic TNFα-levels (day 11)	27±6 *	54±6 *

Data is depicted as mean ± standard error * p<0.05,

^**p<0.01,

^***p<0.001, DSS: Dextrane sodium sulfate; TNFα: tumor necrosis factor-α.

Data are depicted as % improvement of the dextrane sulfate sodium (DSS) treatment groups versus DSS methocel groups.