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. 2013 Feb 28;8(2):e54016. doi: 10.1371/journal.pone.0054016

Figure 4. Effect of Lip-PLP on M1 and M2 marker expression within the synovium after local M1 activation.

Figure 4

Macrophages of the synovial lining in the knee joints were activated towards M1 by intra-articular injection of LPS and IFN-γ for 24 hours and were subsequently treated by intra-articular injection of Lip-PLP or saline for 24 hours. A: Frontal knee joint sections of mice after local M1 activation and subsequent treatment with Lip-PLP or saline and naïve mice. B+C: Expression of M1 (B) and M2 (C) markers in the synovium. RE = Relative Expression compared to values of GAPDH. Values represent the mean +/− SD of eight mice. UD = undetectable. Statistical significance was determined by Student's t-test. * = P<0.05, ** = P<0.01 compared to saline treatment.