Table 4. Parameter values of the Miao split model using the Miao et al. model and data [23].
Description* | Parameter | Value |
Infectivity of virions | 2.5 mL⋅⋅d−1 | |
Target cell regeneration rate | 1.2 d−1 | |
Death rate of infectious cells | 0.47 d−1 | |
Viral titer clearance rate | 6.9 d−1 | |
Viral production rate by infectious cells | 100⋅mL−1⋅d−1 (fixed) | |
Initial number of susceptible cells | 6.5 | |
Initial virus concentration | 1473⋅mL−1(fixed) | |
Killing rate of infectious cells by CTLs | 5.6 d−1 | |
Removal rate of virions by IgG Abs | 3.0mL⋅(pg⋅d)−1 | |
Removal rate of virions by IgM Abs | 6.5 mL⋅(pg⋅d)−1 |
See supplemental material S2 for a description of this model.