Table 1. Association of Notch1 or Notch3 expression with clinicopathologic factors of the HCC patients.

Tumor characteristic	n	Notch1		p-value	χ2	Notch3		p-value	χ2
		High(5–12 score)	Low(0–4 score)			High(5–12 score)	Low(0–4 score)
All cases	86	46(53.5%)	40(46.5%)			45(52.3%)	41(47.7%)
Gender
Male	54	29(53.7%)	25(46.3%)	0.959	0.003	27(50.0%)	27(50.0%)	0.575	0.315
Female	32	17(53.1%)	15(46.9%)			18(56.3%)	14(43.8%)
Age (years)
≤50	48	26(54.2%)	22(45.8%)	0.887	0.020	27(56.3%)	21(43.8%)	0.413	0.671
>50	38	20(52.6%)	18(47.4%)			18(47.4%)	20(52.6%)
Tumor location
Left	40	18(45.0%)	22(55.0%)	0.141	2.166	19(47.5%)	21(52.5%)	0.403	0.698
Right	46	28(60.9%)	18(39.1%)			26(56.5%)	20(43.5%)
Tumor size (cm)
≤5	36	11(30.6%)	25(69.4%)	<0.001*	13.090	23(63.9%)	13(36.1%)	0.068	3.319
>5	50	35(70.0%)	15(30.0%)			22(44.0%)	28(56.0%)
Tumor grade (differentiation)
Well	29	22(75.9%)	7(24.1%)	0.003*	8.804	14(48.3%)	15(51.7%)	0.592	0.288
Moderately or poorly	57	24(42.1%)	33(57.9%)			31(54.4%)	26(45.6%)
Metastasis
Yes	24	17(70.8%)	7(29.2%)	0.045*	4.026	19(79.2%)	5(20.8%)	0.002*	9.614
No	62	29(46.8%)	33(53.2%)			26(41.9%)	36(58.1%)
Venous invasion
+	16	13(81.3%)	3(18.8%)	0.014*	6.090	13(81.3%)	3(18.7%)	0.010*	6.593
–	70	33(47.1%)	37(52.9%)			32(45.7%)	38(54.3%)
Satellite lesions
+	24	13(54.2%)	11(45.8%)	0.937	0.006	17(70.8%)	7(29.2%)	0.033*	4.571
–	62	33(53.2%)	29(46.8%)			28(45.2%)	34(54.8%)
Tumor number
Solitary	65	32(49.2%)	33(50.8%)	0.164	1.940	35(53.8%)	30(46.2%)	0.619	0.247
Multiple	21	14(66.7%)	7(33.3%)			10(47.6%)	11(52.4%)
AJCC TNM stage
I and II	24	4(16.7%)	20(83.3%)	<0.001*	18.143	13(54.2%)	11(45.8%)	0.832	0.045
III and IV	62	42(67.7%)	20(32.3%)			32(51.6%)	30(48.4%)
AFP (ng/ml)
≤400	18	7(38.9%)	11(61.1%)	0.163	1.950	9(50.0%)	9(50.0%)	0.824	0.049
>400	68	39(57.4%)	29(42.6%)			36(52.9%)	32(47.1%)

^*Statistically significant difference.