Fig. 6.

Role of IGF-I in the regulation of MuRF1. Immediately prior to the IP injection of alcohol (75 mmol/kg) or saline, rats were injected subcutaneously with a binary complex consisting of IGF-I and its natural binding partner, IGF binding protein-3, or an equal volume of saline. Blood and tissues were sampled 8 h after administration of alcohol. Values are expressed as means ± SE for n = 7 or 8 rats per group. For mRNA data, values from the saline-injected control group were set at 1.0 AU. ^a,b,cMeans with different letters are statistically different from one another (P < 0.05).