Figure 4.

Schematic representations of potential mechanisms of amyloid/lipid association. (A) A schematic representation of simplified, undisrupted bilayer is presented. This bilayer structure can be perturbed by (B) amyloid-protein insertion or (C) association of amphiphilic α-helices lipid-binding domains. Such scenarios could lead to membrane thinning and non-specific membrane leakage. (D) Many amyloid-forming proteins have been shown to form pore-like structures that can act as unregulated ion-selective channels.