Table 2.
Human PBPK model parameters for benzene (reproduced from Brown et al. (1998) with permission from John Wiley & Sons).
| Parameter | Male | Female |
|---|---|---|
| Body weight (kg) | 70 | 60 |
| Alveolar ventilation (L/h) | 450 | 363 |
| Cardiac output (L/h) | 336 | 288 |
| Blood flow fractions (%) | ||
| Liver | 25 | 25 |
| Fat | 8 | 8 |
| Slow perfused (muscle and skin) | 28.5 | 28.5 |
| Rich perfused (brain, kidney and heart) | 38.5 | 38.5 |
| Tissue volume fractions (%) | ||
| Liver | 2.6 | 2.3 |
| Fat | 20 | 30 |
| Slowly perfused | 64 | 55 |
| Richly perfused | 6 | 5 |
| Partition coefficients | ||
| Blood/air | 7.8 | 8.2 |
| Liver/blood | 2.95 | 2.8 |
| Fat/blood | 54.5 | 51.8 |
| Slow perfused/blood | 2.05 | 2 |
| Rich perfused/blood | 1.92 | 1.8 |
| Metabolic constants | ||
| Km – Michaelis–Menten (mg/L) | 0.35 | 0.35 |
| V max – maximum velocity (mg/h) | 13.89 | 19.47 |