Table 5.
Agency/guideline | Critical effect | Endpoint | Uncertainty factor | Guideline value | Reference |
---|---|---|---|---|---|
Non-cancer | |||||
USEPA RfC | Decreased lymphocyte count in workers | BMCL = 8.2 mg/m3 | 300 | 3 × 10−2 mg/m3 | USEPA (2003) |
EU risk assessment report | Decreased lymphocyte count in workers | NOAEC = 3.2 mg/m3 | None | 3.2 mg/m3 | European Chemicals Bureau (2008) |
Cancer | |||||
USEPA | Leukemia in workers | Low-dose linearity utilizing maximum likelihood estimates | Not applicable | 1 × 10−5 risk (1.3–4.5 µg/m3) | USEPA (2003) |
European Commission Air Quality Standards | 5 µg/m3 | http://ec.europa.eu/environment/air/quality/standards.htm |
BMCL = the 95% lower bound on the benchmark concentration. NOAEC = no observed adverse effect concentration.