Table 3.

Nonplatinum chemotherapy in platinum-resistant recurrent disease

Study	N	Regimen	% platinum-resistant (<6 months)	Overall RR	Platinum-resistant RR	Median PFS	Median OS
ten Bokkel	114	Paclitaxel	52%	13%	7%	14 weeks	43 weeks
Huinink et al24	112	Topotecan	54%	21%	13%	23 weeks	61 weeks
Gordon et al23	239	Liposomal doxorubicin	54%	20%	12%	18 weeks	60 weeks
	235	Topotecan	53%	17%	7%	17 weeks	57 weeks P = 0.038
O’Byrne et al25	107	Liposomal doxorubicin	60%	19%		22 weeks	46 weeks
	107	Paclitaxel	63%	23%		22 weeks	56 weeks
Gore et al26	266	Topotecan (PO)		13%	8%	13 weeks	51 weeks
		Topotecan (IV)		20%	8%	17 weeks	58 weeks
Mutch et al27	195	Liposomal doxorubicin			8.3%	3.1 months	13.5 months
		Gemcitabine			6.1%	3.6 months	12.7 months

Abbreviations: IV, intravenously; N, number; OS, overall survival; PFS, progression-free survival; PO, oral administration; RR, relative risk.