Table 3.
Multivariate analysis of 5-year disease-free survival and melanoma-specific survival
| Clinical and pathological factors | Disease-free survival | P value | Melanoma-specific survival | P value |
|---|---|---|---|---|
| Method of diagnosis |
|
0.6 |
|
0.01 |
| Sentinel lymph node biopsy |
1 |
|
1 |
|
| Clinical |
1.1 (0.7 to 1.7) |
|
1.7 (1.0 to 3.0) |
|
| Primary sitea |
|
0.05 |
|
0.07 |
| Trunk |
1 |
|
1 |
|
| Lower extremity |
0.5 (0.3 to 0.9) |
|
0.6 (0.3 to 1.1) |
|
| Unknown |
1.1 (0.3 to 3.6) |
|
21.7 (0.5 to 5.6) |
|
| T stage |
|
0.05 |
|
0.09 |
| T1 to T2 |
1 |
|
1 |
|
| T3 |
2.2 (1.2 to 4.1) |
|
2.5 (1.1 to 5.6) |
|
| T4 |
1.6 (0.8 to 3.0) |
|
1.6 (0.6 to 3.8) |
|
| Ulcerationb |
|
0.3 |
|
0.06 |
| No |
1 |
|
1 |
|
| Yes |
1.3 (0.7 to 2.3) |
|
1.9 (1.0 to 3.7) |
|
| Number of positive lymph nodes |
|
0.006 |
|
0.003 |
| 1 (N1) |
1 |
|
1 |
|
| 2 or 3 (N2) |
1.2 (0.6 to 2.2) |
|
1.6 (0.7 to 3.5) |
|
| ≥4 (N3) |
3.6 (1.6 to 7.8) |
|
4.7 (1.9 to 11.5) |
|
| Extent of nodal involvement |
|
0.001 |
|
0.002 |
| Superficial |
1 |
|
1 |
|
| Superficial + deep | 2.6 (1.4 to 4.6) | 2.8 (1.5 to 5.5) |