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Cocrystallized structure of the C-terminal DNA-binding domain of AgrA (residues 137–238) with a DNA pentadecamer duplex (PDB accession code 3BS1). The structure indicates that three amino acid residues, H169 (blue), N201(orange), and R233 (green), make specific contacts with the DNA complex. Indeed, the importance of residues H169 and R233 in DNA binding was confirmed by alanine mutagenesis and subsequent isothermal titration calorimetry studies.73
