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(a) FUS experimental setup: (1) a single-element FUS transducer, (2) a plastic bag containing degassed water to couple the sonication path to the scalp, (3) laser pointers, and (4) a MRI-compatible stereotactic frame. (b) Illustration of the sonication guidance, where the distance between the laser dots on the scalp (7.4 mm) determined the sonication depth. The arrow indicates the ∼3 mm offset distance and direction (left thalamus in the presented case).
