Table 1.
Baseline characteristics and medical history
| Prasugrel 5 mg n = 41* | Placebo n = 21 | p value | |
|---|---|---|---|
|
Age (mean, years) |
32.9 |
31.5 |
0.553 |
|
Female, n (%) |
21 (51.2) |
9 (42.9) |
0.598 |
|
Body Weight (mean, kg) |
78.3 |
68.6 |
0.021 |
|
Hydroxyurea |
18 |
9 |
|
|
Sickle-cell Genotype, n (%) |
|
|
>0.999 |
| Hb S/ β0 thalassemia |
2 (5.0) |
1 (4.8) |
|
| Hb S/ βthalassemia |
4 (10.0) |
2 (9.5) |
|
| Hb SC |
10 (25.0) |
5 (23.8) |
|
| Hb SS |
24 (60.0) |
13 (61.9) |
|
|
Pain Intensity |
|
|
0.473 |
| Mean |
1.8 |
2.4 |
|
| Minimum |
0.0 |
0.0 |
|
| Median |
0.0 |
2.0 |
|
| Maximum |
9.0 |
7.0 |
|
|
Medical History, n (%) |
|
|
|
| Vaso-occlusive crisis |
25 (61.0) |
12 (57.1) |
|
| Acute chest syndrome |
9 (22.0) |
2 (9.5) |
|
| Hepatic sequestration |
0 |
1 (4.8) |
|
| Splenectomy |
7 (17.1) |
5 (23.8) |
|
| Systemic hypertension |
11 (26.8) |
2 (9.5) |
|
| Pulmonary hypertension |
7 (17.1) |
2 (9.5) |
|
| Renal failure |
1 (2.4) |
0 |
|
| Hepatic disease† |
1 (2.4) |
0 |
|
| Renal insufficiency |
0 |
1 (4.8) |
|
|
Laboratory Values, mean (SD) |
|
|
|
| Hemoglobin (g/L) |
10.4 (1.8) |
9.8 (2.0) |
0.297 |
| White Blood Cells (x109/L) |
8.2 (3.4) |
8.3 (2.7) |
0.929 |
| Platelets (x109/L) | 310.6 (180.4) | 340.5 (117.5) | 0.561 |
*1 patient was found not to have SCD but to have only β-thalassemia trait.
†Other than sequestration.