Figure 8. Nrf2 expression attenuates the fragmentation of mitochondira in striatal cells.

Striatal cells were transfected with mito-mCherry as well as GFP, Nrf2, Keap1, or p62. Two days after transfection, cells were fixed with 4% paraformaldehyde and the morphology of mitochondria was assessed. A-B, The exogenous expression of Nrf2 reduces the number of cells with fragmented mitochondria in the striatal cells. In contrast, Keap1 expression results in a strong trend of increase in the number of cells with fragmented mitochondria in the both cell types, while p62 expression does not seem to have any effect. More than 200 cells of each cell type were assessed for each independent experiment. n = 4. Data shown are mean ± SE. *P<0.05 vs. GFP.