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. 2013 Mar 1;8(3):e57974. doi: 10.1371/journal.pone.0057974

Figure 1. Alignment of SET domain methyltransferase proteins.

Figure 1

Amino acid sequences of SET domain proteins from S. cerevisiae Set1 (Set1_Sc), H. sapiens MLL1, N. crassa Dim-5, and H. sapiens Set7/9 are aligned to show conserved residues. Gray bar above the aligned sequences indicates the SET and post-SET domains. Amino acid substitutions of Set1 analyzed here are indicated above and boxed within the alignment. The conserved SET motifs I-IV are shown below the alignment with black bars and Roman numerals. The numbers at the right end of the aligned sequences refer to the amino acid at the end of sequence. Numbers below the alignment (e.g. Y245, H293, etc.) indicate amino acids and their positions in Set7/9.