Table 2.
Demographics and clinical characteristics, by co-receptor tropism
|
FPR Criteria |
FPR = 10 |
FPR = 5.75 |
||||
|---|---|---|---|---|---|---|
| Patient characteristics | CXCR4 (n=44), n (row %) | R5 (n=66), n (row %) | P-value | CXCR4 (n=35), n (row %) | R5 (n=75), n (row %) | P-value |
|
Median age (median, IQR) |
36.9 [28.8–45.4] |
36.4 [27.6–44.6] |
0.665 |
39.7 [29.4–45.4] |
35.6 [27.6–45.0] |
0.539 |
|
Male gender |
38 (39.1) |
59 (61.0) |
0.765 |
30 (30.9) |
67 (69.1) |
0.752 |
|
Ethnicity |
|
|
|
|
|
|
| Chinese |
34 (77.3) |
54 (81.8) |
0.630 |
27 (77.1) |
61 (81.3) |
0.617 |
| Non-Chinese |
10 (22.7) |
12 (18.2) |
|
8 (22.9) |
14 (18.7) |
|
|
Transmission risk |
|
|
|
|
|
|
| Heterosexual |
20 (45.5) |
30 (45.5) |
0.945 |
15 (42.9) |
36 (48.0) |
0.502 |
| MSM |
23 (52.3) |
33 (50.0) |
|
14 (40.0) |
32 (42.7) |
|
| Othersa |
1 (3.0) |
3 (4.5) |
|
6 (17.1) |
7 (9.3) |
|
|
CD4 count at presentation (median, IQR) |
226 [32–402] |
333 [200–462] |
0.013 |
219 [35–336] |
333 [189–470] |
0.025 |
|
Evidence of recent seroconversion(n=25) |
|
|
|
|
|
|
| Subtype B |
2 (8.0) |
4 (16.0) |
0.011 |
1 (4.0) |
5 (20.0) |
0.007 |
| CRF01_AE |
3 (12.0) |
10 (40.0) |
|
3 (12.0) |
10 (40.0) |
|
| CRF51_01B |
5 (2.0) |
0 (0.0) |
|
5 (20.0) |
0 (0.0) |
|
| Othersc | 0 (0.0) | 1 (4.0) | 0 (0.0) | 1 (4.0) | ||
Abbreviations: IQR, interquartile range; MSM, men who have sex with men; FPR, false-positive rate.
a Blood transfusion, intravenous drug use (IVDU), bisexual.
b Other subtypes: CRF02_AG, CRF34_01B, CRF07_BC, CRF15_01B.
c Other subtypes: CRF33_01B.