Table 1. Association of patient characteristics with tumor p53 mutational status.
| All Cases (n = 173) | p53 mutation No (n = 145) | p53 mutation Yes (n = 28) | P value* t-test | |
| Age at diagnosis (mean ± SD; n = 173) | 54.0 ± 13.3 | 54.0 ± 13.2 | 53.6 ± 14.4 | 0.89 |
| Body mass index (mean ± SD; n = 168)** | 28.9 ± 8.4 | 28.9 ± 8.7 | 29.1 ± 6.4 | 0.93 |
| Tumor-associated macrophages (CD68) (mean ± SD; n = 172)** | 97.5 ± 58.6 | 92.9 ± 57.3 | 120.8 ± 60.6 | 0.021 |
| Smoking in pack years [mean (range); n = 164]** | 9.8 (0–112) | 10.3 (0–112) | 7.6 (0–111) | 0.08*** |
| N** | N (%)** | N (%)** | Fisher’s exact test | |
| Race/ethnicity | 0.10 | |||
| African-American | 98 | 78 (80) | 20 (20) | |
| European-American | 75 | 67 (89) | 8 (11) | |
| Household income | 0.045 | |||
| ≤ $60k/year | 135 | 109 (81) | 26 (19) | |
| > $60k/year | 38 | 36 (95) | 2 (5) | |
| Education** | 1.0 | |||
| No High school degree | 39 | 33 (85) | 6 (15) | |
| High school degree or more | 132 | 110 (83) | 22 (17) | |
| Stage at diagnosis (TNM) ** | 1.0 | |||
| ≤ Stage II | 131 | 108 (82) | 23 (18) | |
| Stage III/IV | 25 | 21 (84) | 4 (16) | |
| Node status** | 0.009 | |||
| Negative | 99 | 77 (78) | 22 (22) | |
| Positive | 61 | 57 (93) | 4 (7) | |
| Tumor grade** | 0.050 | |||
| Low (1 & 2) | 81 | 72 (89) | 9 (11) | |
| High (3) | 70 | 53 (76) | 17 (24) | |
| Estrogen receptor | 0.034 | |||
| Negative | 71 | 54 (76) | 17 (24) | |
| Positive | 102 | 91 (89) | 11 (11) | |
| p53 IHC | 0.001 | |||
| Negative | 119 | 108 (91) | 11 (9) | |
| Positive | 54 | 37 (69) | 17 (31) |
*
P value comparing patient characteristics by tumor p53 mutational status
**
Cases with missing information are not included
***
Mann-Whitney rank sum test
Annual household income, race/ethnicity, and education are self-reported. Tumor-associated macrophages were counted as CD68-positive cells. Pack years: (packs smoked per day) x (years as a smoker). BMI = kg/m2; SD = standard deviation, IHC = immunohistochemistry.