Fig. 1.

Effects of sortilin deficiency on memory deficits. (A) At 6 months of age AD10 transgenic mice show a deficit in non-spatial working memory which is absent in Sort1^−/− and AD10×Sort1^−/− mice, (B) At 12 months of age both AD10 and Sort1^−/− mice showed a memory deficit which was prevented in AD10×Sort1^−/− mice, (C) During the acquisition phase of the Morris water maze test performed at 12 months of age, AD10 mice did not learn as well as WT mice or Sort1^−/− mice while AD10×Sort1^−/− showed an intermediate acquisition pattern and (D–F) During the probe phase, only WT mice were able to remember the target quadrant at all ages, while AD10 mice showed always a spatial memory impairment. The deficit appeared also in 6 (E) and 12 (F) month-old Sort1^−/− mice while the crossing of AD10 to Sort1^−/− mice only temporally protected from spatial memory deficit at 6 months of age (E). In A, B bars are representative of mean ± SEM. ^∗P < 0.05 new versus old object. In C–F Bars and points are representative of mean  ± SEM. In C, ^∗P < 0.05 versus WT mice. In D–F, ^∗P < 0.05 time in target quadrant versus adjacent and opposite quadrants.