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. 2013 Feb 15;431(3):579–585. doi: 10.1016/j.bbrc.2013.01.007

Fig. 2.

Fig. 2

Measurements of APP/Aβ clusters of dystrophic neurites in the hippocampus and of phosphorylated tau in lateral entorhinal cortex. (A) Quantification of the number of clusters at 3, 6 and 12 months of age. (B–D) Qualitative images of APP/Aβ amyloid clusters in (B) AD10, (C) Sort1−/− and (D) AD10×Sort1−/− hippocampus at 12 months of age. (E–G) Qualitative images of phosphotau-imunoreactive neurons in the lateral entorhinal cortex from (E) AD10 (E) Sort1−/− and (G) AD10×Sort1−/− mice at 12 months of age. (H) Quantification of the number of phospho-immunoreactive neurons at 3, 6 and 12 months of age in the LEC. All transgenic mice show an increase of phospho-tau immunoreactive neurons from 3 months of age with respect to WT mice. Bars are representative of mean  ± SEM. ∗P < 0.05 versus WT mice. #P < 0.05 versus AD10 and Sort1−/− mice. Scale bar = 250 μm.