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. 2013 Mar 1;8(3):e55667. doi: 10.1371/journal.pone.0055667

Figure 1. The effects of recombinant wild type TIMP-3 (WT-TIMP-3), N-terminal TIMP2: C-terminal TIMP-3 chimera (NT2: CT3) and the NH3-terminal domain of TIMP-3 (NT3) on binding of 50 ng/ml soluble(s) VEGFR-1 or VEGFR-2 to immobilized VEGF.

Figure 1

A competitive ELISA assay was used as described under “Materials and Methods”. (a) description of WT-TIMP-3, N-T3 and NT2:CT3 (b). WT-TIMP-3 and NT2: CT3 inhibit sVEGFR-2-VEGF complexes in a concentration-dependent manner. (c). N-T3 has no effect on sVEGFR-2-VEGF complexes. (d). WT-TIMP-3, NT2 and N-T3 are unable to block sVEGFR-1-VEGF complexes.