Table 3.
Numbers of patients with predefined events (PDEs) and numbers of PDEs by age category
| Variable | Age category | |||
|---|---|---|---|---|
| Age >80 years (n = 395) | Total (n = 3596)a | |||
| n (%) [95 % CI] | Events | n (%) | Events | |
| All PDEs reported | 108 (27.3) [22.9–31.7] | 167 | 636 (17.7) | 911 |
| Notable individual PDEs | ||||
| MI and angina | 11 (2.8) [1.2–4.4] | 13 | 59 (1.6) | 66 |
| Stroke | 5 (1.3) [0.2–2.4] | 6 | 49 (1.4) | 55 |
| TIA | 4 (1.0) [0.0–2.0] | 6 | 33 (0.9) | 38 |
| Intermittent claudication/digital ischaemia | 2 (0.5) [0.0–1.2] | 2 | 12 (0.3) | 15 |
| Venous thromboembolic events | 7 (1.8) [0.5–3.1] | 8 | 44 (1.2) | 49 |
| Thromboembolic eventsb total | 25 (6.3) [3.9–8.7] | 35 | 186 (5.2) | 223 |
| Congestive heart failure | 13 (3.3) [1.5–5.1] | 14 | 35 (1.0) | 36 |
| Major haemorrhage | 10 (2.5) [1.0–4.1] | 12 | 58 (1.6) | 69 |
| Other cardiovascular symptoms | 23 (5.8) [3.5–8.1] | 29 | 129 (3.6) | 159 |
| Transformationc | 15 (3.8) [1.9–5.7] | 15 | 106 (2.9) | 113 |
| Non-PDE death | 44 (11.1) [8.0–14.2] | 44 | 103 (2.9) | 103 |
CI confidence interval, MI myocardial infarction, TIA transient ischaemic attack
aPatients with missing data: n = 2
bThromboembolic events defined as: MI and angina, stroke, TIA, intermittent claudication/digital ischaemia, venous thromboembolic events. Note: Some patients experienced more than one thromboembolic event
cTransformation to: acute leukaemia, myelodysplasia, myelofibrosis and ‘other’