Table 1. Characteristics of patients with ALI who were transfused with a blood product compared with those who were not transfused.
| Baseline Characteristics | No Transfusions | With Transfusions | p |
|---|---|---|---|
| Number | 163 | 152 | |
| Age in yrs, median (interquartile range) | 3.13 yrs (0–17.7 yrs) | 3.60 yrs (0–17.4 yrs) | 0.54 |
| Male, n (%) | 92 (56) | 86 (57) | |
| Medical history, n (%) | <0.001 | ||
| Premature at birth | 23 (14) | 19 (13) | |
| Genetic or neurologic abnormality | 51 (31) | 27 (18) | |
| Oncologic process | 4 (2) | 22 (14) | |
| History of pulmonary disease | 24 (15) | 9 (6) | |
| Other medical history | 47 (29) | 50 (33) | |
| No significant medical history | 14 (9) | 25 (16) | |
| Ethnicity, n (%) | 0.56 | ||
| White | 66 (40) | 55 (37) | |
| African American | 31 (19) | 31 (21) | |
| Hispanic/Latino | 30 (18) | 28 (19) | |
| Asian | 9 (6) | 15 (10) | |
| Other | 27 (17) | 20 (13) | |
| Diagnosis at ALI onset, n (%) | <0.01 | ||
| Pneumonia | 75 (46) | 40 (26) | |
| Aspiration | 30 (18) | 19 (13) | |
| Sepsis | 5 (3) | 35 (23) | |
| Near drowning | 20 (12) | 8 (5) | |
| Cardiac disease | 11 (7) | 12 (8) | |
| Other | 22 (14) | 38 (25) | |
| Pao2/Fio2 at ALI onset, mean ± sd | 164 ± 77 | 159 ± 72 | 0.58 |
| Mechanically ventilated at onset of ALI, n (%) | 112 (69) | 119 (78) | 0.06 |
| ≥2 nonpulmonary OSF at onset of ALI, n (%) | 32 (20) | 93 (61) | <0.01 |
| Unadjusted PRISM III score at onset of ALI | 8.1 ± 8.0 | 12.7 ± 8.5 | <0.01 |
| Total fluid balance, mean ± sda | 27.7 ± 54.0 | 43.5 ± 70.1 | 0.03 |
| Outcomes | |||
| Ventilator-free days, mean ± sd | 17 ± 11 | 12 ± 10 | <0.01 |
| PICU mortality, n (%) | 28 (17) | 41 (27) | 0.04 |
ALI, acute lung injury; OSF, organ system failure; PRISM, Pediatric Risk of Mortality; PICU, pediatric intensive care unit.
a
Total fluid in (mL/kg patient weight)—total fluid out (mL/kg patient weight) over the first 72 hrs following the diagnosis of ALI.