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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Biomaterials. 2012 Feb 21;33(14):3756–3769. doi: 10.1016/j.biomaterials.2012.01.054

Fig. 4.

Fig. 4

Representative TEM images of inactivated influenza PR8 virus vaccine. (a) PR8 virus (a) in DPBS at 4 °C, (b) after resuspension in DPBS from an amorphous coating and (c) after resuspension in DPBS from a crystallized coating. The insets show magnified virus images. Virus particles in (a) and (b) show typical intact viral structures, whereas in the virus particles in (c) appears significantly destroyed. TEM analysis shows that crystallization induces destruction of influenza virus. Samples received negative staining of the viral surface with 1.5% phosphotungstic acid (pH = 7.0) before TEM imaging.