Table 1.
Raw startle values (group means) from each of the three paradigms in the primary experiment (open cells). Shaded cells indicate mean percent-of-baseline measures (e.g., post-infusion divided by pre-infusion × 100, in the case of CRF-enhanced startle). These values are based on the mean of the individual animal's percent-of-baseline scores and are, therefore, close but not exactly equivalent to the percent of baseline score which would be calculated from the group mean startle values shown in the unshaded cells.
| Dose (mg/kg) | CRF-Enhanced Startle Tests | Light-Enhanced Startle Tests | Fear-Potentiated Startle Test | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||||
| CSF Control Infusion | CRF Infusion | Dark->Dark Control Session | Dark->Light Session | ||||||||||||
|
| |||||||||||||||
| Pre-Infusion | Post-Infusion | Post CSF as % of Pre CSF | Pre-Infusion | Post-Infusion | Post CRF as % of Pre CRF | Dark Phase I | Dark Phase II | Phase II as % of Phase I | Dark Phase I | Light Phase II | Phase II as % of Phase I | Noise Alone | Fear CS + Noise | w/CS as a % of Noise Alone | |
|
| |||||||||||||||
| 0 | 0.78 | 0.6 | 78 | 0.82 | 1.05 | 137 | 0.67 | 0.59 | 91 | 0.68 | 0.77 | 118 | 0.92 | 1.54 | 176 |
| 0.1 | 0.65 | 0.44 | 68 | 0.73 | 0.9 | 139 | 0.53 | 0.59 | 109 | 0.7 | 0.82 | 124 | 1.06 | 1.82 | 173 |
| 0.3 | 0.85 | 0.61 | 74 | 0.78 | 1.22 | 174 | 0.7 | 0.79 | 124 | 0.61 | 0.77 | 136 | 1 | 1.79 | 196 |
| 1 | 1.18 | 1.23 | 104 | 1.29 | 2.38 | 187 | 0.93 | 0.93 | 92 | 1.08 | 1.13 | 101 | 1.18 | 2.05 | 164 |
| 3 | 1.14 | 0.95 | 81 | 1.37 | 0.96 | 79 | 0.88 | 0.71 | 80 | 0.99 | 0.87 | 90 | 1.09 | 1.61 | 143 |
| 10 | 1.16 | 0.82 | 71 | 1.15 | 0.98 | 88 | 0.71 | 0.76 | 130 | 0.74 | 0.72 | 104 | 1.12 | 1.67 | 156 |
| 30 | 1.06 | 0.71 | 65 | 1.32 | 1.14 | 72 | 0.92 | 0.75 | 83 | 1.09 | 0.96 | 86 | 1.02 | 1.82 | 178 |
| 60 | 1.15 | 0.61 | 56 | 1.35 | 0.91 | 69 | 0.59 | 0.49 | 81 | 0.58 | 0.63 | 111 | 0.69 | 1.03 | 156 |