Figure 11.
a) Schematic representation of PLL “bowtie” dendrimers.56 Representative enhancement kinetics as revealed by T1-weighted dynamic 3D MR imaging (spoiled gradient recalled sequence, SPGR) of a normal rat at the level of the liver after intravenous injection of PEG12000-Gen4-(Gd-DTPA)8 (upper row) and PEG3400-Gen5-(Gd-DTPA)13 (lower row), respectively, at a dose of 0.04 mmol Gd/kg. The blood enhancement as seen in the inferior vena cava is relatively prolonged being still visible for at least 30 and 60 min, respectively, for these two agents. Their monoexponential blood half-lives were calculated to be 36 and 73 min (mean values), respectively. Figure adapted with permission from: Fu, Y.; Raatschen, H.–J.; Nitecki, D. E.; Wendland, M. F.; Novikov, V.; Fournier, L. S.; Cyran, C.; Rogut, V.; Shames, D. M.; Brasch, R. C. Biomacromolecules 2007, 8, 1519–29.56