a) PEG-DTPA copolymers created by Ladd and coworkers, shown without the chelated Gd(III) for clarity. b) Whole-blood R1 versus molecular weight of the polymer at various time points after injection in rabbits. Reproduced with permission from Desser, T. S.; Rubin, D. L.; Muller, H. H.; Qing, F.; Khodor, S.; Zanazzi, G.; Young, S. W.; Ladd, D. L.; Wellons, J. A.; Kellar, K. E.; Toner, J. L.; Snow, R. A. J. Magn. Res. Imag.
1994,
4, 467–72.22