A) Diagram describing generations of PAMAM dendrimer and showing chelate connectivity with primary amines.41,42 Reproduced with permission from Kobayashi, H.; Kawamoto, S.; Jo, S. –K.; Bryant, H. L.; Brechbiel, M. W.; Star, R. A. Bioconjug. Chem.
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14, 388–94. B) In vivo rat images showing dendrimer generation effect on contrast agent localization.43 Reproduced with permission from Kobayashi, H.; Brechbiel, M. W. Mol. Imaging,
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2, 1–10.