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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 15;64:348–356. doi: 10.1016/j.neuropharm.2012.07.016

Table 1.

Effects of drug treatment on acoustic startle reactivity.

Treatments Wild type DAT KO
Nicotine treatments
    Saline 101.8 ± 22.8 109.1 ± 17.3
    Nicotine 0.3 101.8 ± 22.8 121.8 ± 25.0
    Nicotine 1 106.6 ± 32.4 112.6 ± 24.4
    Nicotine 3   77.5 ± 22.1 103.8 ± 18.8
Nicotine and nACh receptor antagonists treatments
    sal–sal   95.2 ± 18.2   78.7 ± 14.4
    sal–nic1 108.7 ± 19.4
    MCA5–nic1 109.8 ± 18.6
    MCA10–nic1   83.6 ± 22.8
    DHβE1–nic1   85.1 ± 20.5
    DHβE2–nic1 102.0 ± 21.4
    MLA2–nic1   77.2 ± 16.3
    MLA5–nic1 130.5 ± 29.3
Nicotine and 5-HT receptor antagonist treatments
    sal–sal   95.2 ± 18.2   78.7 ± 14.4
    sal–nic1 108.7 ± 19.4
    WAY1–nic1   89.0 ± 20.3
    WAY3–nic1   77.7 ± 15.5
5-HT receptor agonist and antagonist treatments
    sal–sal   94.5 ± 23.3   61.9 ± 9.7
    sal–DPAT0.3   55.1 ± 12.2   51.4 ± 8.7
    sal–DPAT1   87.9 ± 22.2   78.2 ± 13.3
    WAY3–DPAT1   96.4 ± 21.1   60.3 ± 10.7

Values (arbitrary units) represent mean startle magnitude ± SEM. KO, dopamine transporter knockout mice. No significant main effect on acoustic startle reactivity in each treatments was found.